253 Protective and cleansing effect of a skin care product against pollen allergen accumulation in the hair follicle

Environmental airborne elements such as pollutant matters, chemicals, or allergens, pollen allergens accumulate on the skin and more particularly in infundibula of hair follicle due to its specific form function. This accumulation can lead irritation, discomfort even sensitization allergic reactions. Thereby, prevention cleansing these within infundibulum is a key challenge protect skins submitted environmental factors. A new study model was set up mimic allergen deposit onto test effect care product prevent cleanse accumulation. Explants from hairy abdominoplasty were prepared placed Perfex vivo culture supports (Bio-EC). Recombinant Phl p 5b Timothy grass (abcam) applied surface explants for 6 hours proceeded immunohistochemistry visualize Pretreatment with used evaluate preventive protocol quantify curative efficacy. The able completely along when explant prior exposition. strong removal (-83%) accumulated observed cleansed using same product. In conclusion, infundibulum. Protective thanks film forming capacity tested ability could be demonstrated. displayed great double effect, making it an ally allowing processes prevention.